| Pair Name | Cucurbitacin B, Doxorubicin | ||
| Phytochemical Name | Cucurbitacin B (PubChem CID: 5281316 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Cucurbitacin B, Doxorubicin | |||
| Disease Info | [ICD-11: 2D10.Z] | Thyroid cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Expression | IREB2 | hsa3658 | |
| Up-regulation | Phosphorylation | MAPK3 | hsa5595 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | 8505C | Thyroid gland anaplastic carcinoma | Homo sapiens (Human) | CVCL_1054 |
| CAL-62 | Thyroid gland anaplastic carcinoma | Homo sapiens (Human) | CVCL_1112 | |
| 8505C | Thyroid gland anaplastic carcinoma | Homo sapiens (Human) | CVCL_1054 | |
| CAL-62 | Thyroid gland anaplastic carcinoma | Homo sapiens (Human) | CVCL_1112 | |
| Result | Synergistic cytotoxicity of doxorubicin with cucurbitacin B is mediated by B-cell chronic lymphocytic leukemia/lymphoma 2 family proteins, survivin, and reactive oxygen species and modulated by Janus kinase 2/signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2 in anaplastic thyroid carcinoma cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells. Tumour Biol. 2017 Feb;39(2):1010428317692252. doi: 10.1177/1010428317692252. | Click |
